Interaksi Sistem Imun dan Hematologi dalam Mekanisme Pertahanan Tubuh: Tinjauan Imunobiologi
DOI:
https://doi.org/10.63822/gaawrg68Keywords:
Immune System, Hematology, ImmunobiologyAbstract
The immune system and the hematological system are closely interconnected biological systems that play essential roles in maintaining homeostasis and protecting the body against pathogens. This study aimed to comprehensively examine the interaction between the immune and hematological systems from an immunobiological perspective. The study employed a literature review method by analyzing scientific articles published between 2015 and 2025 from national and international journals. The findings indicate that leukocytes, platelets, erythrocytes, and plasma components contribute significantly to immune regulation and defense mechanisms. Cellular interactions involving immune cells, inflammatory mediators, and hematopoietic processes facilitate coordinated responses to infection and tissue injury. Platelets participate in immune signaling and inflammation, while erythrocytes contribute to immune modulation through complement interactions and inflammatory regulation. Furthermore, hematological parameters can serve as important indicators of immune responses in infectious and inflammatory diseases. Overall, the integration of immune and hematological systems is crucial for maintaining physiological balance and supporting effective host defense mechanisms. Understanding this relationship may contribute to the development of improved diagnostic, prognostic, and therapeutic strategies for various diseases.
References
Aguilar, X. F., Mana, M. Mattia, B., Gladys, K. Z., Margaret, D. Chrisostom, A., David, S. A., Michael, K., Jean, P. K. L., Mun, J. I. M., Andreu, C. C., Johan, E., Natascha, M., Oscar, C., Alexander, C., Amaud, B., Genevieve, L., Krupali, P., Satya, P., & Richard, P. (2020). Peste des Petits Ruminants at the Wildlife–Livestock Interface in the Northern Albertine Rift and Nile Basin, East Africa. Journal Viruses, 12 (3), 1-19. https://doi.org/10.3390/v12030293
Anderson, H. L., Brodsky, I. E., & Mangalmurti, N. S. (2018). The evolving erythrocyte: red blood cells as modulators of innate immunity. The Journal of Immunology, 201(5), 1343-1351. https://doi.org/10.4049/jimmunol.1800565
Bahar, M., Anwar, E. N., & Fahira, L. (2023). Hubungan hasil jumlah trombosit dengan hasil IgG IgM pada pasien DBD di Laboratorium RS Gading Medika Kota Bengkulu. Anakes: Jurnal Ilmiah Analis Kesehatan, 9(2), 113-120. https://doi.org/10.37012/anakes.v9i2.1648
Borbouche, M. R., Najla, M., Meriem, B. A., & Imen, B. M. (2017). Lessons From Genetic Studies of Primary Immunodeficiencies in a Highly Consanguineous Population. Frontiers in Immunology Mini Review, 8, 1-8. https://doi.org/10.3389/fimmu.2017.00737
Chen, L., Deng, H., Cui, H., Fang, J., Zuo, Z., Deng, J., ... & Zhao, L. (2017). Inflammatory responses and inflammation-associated diseases in organs. Oncotarget, 9(6), 7204. https://doi.org/10.18632/oncotarget.23208
Delano, M. J., & Ward, P. A. (2016). The immune system's role in sepsis progression, resolution, and long‐term outcome. Immunological reviews, 274(1), 330-353. https://doi.org/10.1111/imr.12499
Dewi, M. S., Nabila, P. S. D., Maya, D. A., Luqyana, S. A., Levina, A. H., Lathifah, KM., & Liss, D. D. A. (2025). Sistem Hematologi dan Imunologi: Sinergi Kompleks dalam Pertahanan Tubuh. Jurnal Ilmiah Multidisiplin, 1(6), 4364-4369. https://doi.org/10.63822/v8zkv291
Firani, N. K., Siti, F. Shinta, O. W. Supriono., Andry, G., & Mustofa, A. (2024). Korelasi Profil Hematologi dan Trombopoietin dengan Terjadinya Perdarahan pada Pasien Sirosis Hepatis. Majalah Kesehatan Fakultas Kedokteran, 11(3), 168-174. https://doi.org/10.21776/majalahkesehatan.2024.011.03.2
Gasparyan, A. Y., Ayvazyan, L., Mukanova, U., Yessirkepov, M., & Kitas, G. D. (2019). The platelet-to-lymphocyte ratio as an inflammatory marker in rheumatic diseases. Annals of laboratory medicine, 39(4), 345. https://doi.org/10.3343/alm.2019.39.4.345
Ginhoux, F., & Guilliams, M. (2016). Tissue-resident macrophage ontogeny and homeostasis. Immunity, 44(3), 439-449. http://dx.doi.org/10.1016/j.immuni.2016.02.024
Hashimi, D., & Kevin, G. (2019). Yoga-Specific Enhancement of Quality of Life Among Women With Breast Cancer: Systematic Review and Exploratory MetaAnalysis of Randomized Controlled Trials. Journal of Evidence-Based Integrative Medicine, 24, 1-9. https://doi.org/10.1177/2515690X19828325
Hermawan, D., Hayati, E., Durachim, A., & Noviar, G. (2023). Pengaruh Waktu dan Suhu Penyimpanan Trombosit Konsentrat terhadap Jumlah Trombsit. Jurnal Kesehatan Siliwangi, 4(1). https://doi.org/10.34011/jks.v4i1.1480
Humaira, Z. Debie, A. Prima, A., & Yuri, H. (2025). Peran Skrining Hematologi Rutin dalam Deteksi Dini Komplikasi pada Pasien Stroke di Wilayah Kerja RSI Siti Rahmah Padang. Jurnal Pengabdian Kolaborasi Inovi IPTEKS, 3(4), 928-931. https://doi.org/10.59407/jpki2.v3i4.2924
Jeremy, R. C., Angela, C. W., & Germaine, W. (2026). Cancer in The Transplant Recipient. Cold Spring Harbor Perspective in Medicine, 1-13. http://perspectivesinmedicine.cshlp.org/
Junianda, W., Jannah, W., Sari, W. P., & Anggriyani, R. (2023). Meta-analisis Kolerasi antara Jumlah Trombosit dengan Karakteristik Pasien dalam Patogenesis Malaria. EKOTONIA: Jurnal Penelitian Biologi, Botani, Zoologi dan Mikrobiologi, 8(2), 90-97. https://doi.org/10.33019/ekotonia.v8i2.4776
Karine, A. P., Marine, G., Blanche, G., Herve, B., Amina, C., Stephane, C., & Christophe, J. (2020). Administration of Extensive Hydrolysates From Caseins and Lactobacillus rhamnosus GG Probiotic Does Not Prevent Cow’s Milk Proteins Allergy in a Mouse Model. Original Research Frontiers in Immunology, 11, 1-12. https://doi.org/10.3389/fimmu.2020.01700
Lippi, G., & Plebani, M. (2020). Laboratory abnormalities in patients with COVID-2019 infection. Clinical chemistry and laboratory medicine (CCLM), 58(7), 1131-1134. https://doi.org/10.1515/cclm-2020-0198
Loviana, N., Savitri, L., Krissanjaya, R., & Kasimo, E. R. (2023). The Correlation Between Widal Diagnostic Test, Total Leukocyte Count, and Platelet Count in Suspected Typhoid Fever Patients at RS Aura Syifa Kediri. Biology, Medicine, & Natural Product Chemistry, 12(2), 555-558. https://doi.org/10.14421/biomedich.2023.122.555-558
Manne, B. K., Denorme, F., Middleton, E. A., Portier, I., Rowley, J. W., Stubben, C., ... & Campbell, R. A. (2020). Platelet gene expression and function in patients with COVID-19. Blood, The Journal of the American Society of Hematology, 136(11), 1317-1329. https://doi.org/10.1182/blood.2020007214
Marshall, J. S., Richard, W., Wade, W., & Harold, L. K. (2018). An introduction to immunology and immunopathology. Allergy, Asthma & Clinical Immunology, 2(49), 6-14. https://doi.org/10.1186/s13223-018-0278-1
Mulyatmo, P. D. S., Wijayanti, D. R., & Yansen, A. (2023). Hubungan Hematokrit Dan Trombosit Dengan Inflamasi Demam Berdarah Dengue Di Prodia Kebayoran Tahun 2020-2021: Relationship Of Hematocrite And Thrombocytes In Inflammation Case Of Dengue Fever At Kebayoran Prodia 2020-2021. Binawan Student Journal, 5(3), 77-82. https://journal.binawan.ac.id/bsj/article/view/670
Nagaraj, M., Ananya, C., Srinivas, B. N. (2015). A Study on the Dispensing Pattern of Over the Counter Drugs in Retail Pharmacies in Sarjapur Area, East Bangalore. Journal of Clinical and Diagnostic Research, 9(8), 11-13. https://doi.org/10.7860/JCDR/2015/12940.6119
Netea, M. G., Domínguez-Andrés, J., Barreiro, L. B., Chavakis, T., Divangahi, M., Fuchs, E., ... & Latz, E. (2020). Defining trained immunity and its role in health and disease. Nature Reviews Immunology, 20(6), 375-388. https://doi.org/10.1038/s41577-020-0285-6
Pinho, S., & Frenette, P. S. (2019). Haematopoietic stem cell activity and interactions with the niche. Nature reviews Molecular cell biology, 20(5), 303-320. https://doi.org/10.1038/s41580-019-0103-9
Pretini, V., Koenen, M. H., Kaestner, L., Fens, M. H., Schiffelers, R. M., Bartels, M., & Van Wijk, R. (2019). Red blood cells: chasing interactions. Frontiers in physiology, 10, 945. https://doi.org/10.3389/fphys.2019.00945
Ratajczak, M. Z., & Kucia, M. (2022). Hematopoiesis and innate immunity: an inseparable couple for good and bad times, bound together by an hormetic relationship. Leukemia, 36(1), 23-32. https://doi.org/10.1038/s41375-021-01482-0
Rayes, J., Bourne, J. H., Brill, A., & Watson, S. P. (2020). The dual role of platelet‐innate immune cell interactions in thrombo‐inflammation. Research and practice in thrombosis and haemostasis, 4(1), 23-35. https://doi.org/10.1002/rth2.12266
Sabatudung, C., Michael, B.B., & Norma, T. K. (2023). Gambaran Hematologi Rutin dan D-Dimer Pasien Covid-19 Kota Kupang. Journal of Indonesia Medical Laboratory and Science, 4(1), 14-24. https://doi.org/10.53699/joimedlabs.v4i1.125
Safitri, E. K., Latifah, N. A., Luluk, L., Nabila, F. A. Z., Nina, M. S., Rahmadani, E. N. S., & Liss, D. D. A. (2025). Dampak Gangguan Sistem Imun Terhadap Hematologi Pasien. Jurnal Ilmiah Multidisiplin, 1(6), 4371-4380. https://doi.org/10.63822/wwrc2571
Sutanto, Y. S., Hendra, A. Akhmad, S., Sihsusetyaningtyas, T. S. (2024). Differences in White Blood Cells, Neutrophil-to-Lymphocyte Ratio, Tumor Necrosis Factor-α Based on Procalcitonin Level In Community-Acquired Pneumonia Patients. Jurnal Respirpologi Indonesia, 44(3), 236-241. https://doi.org/10.36497/jri.v44i3.632
Taggara, N. T., Perdana, N., Anggeraini, S., & Faidah, N. (2019). Analisis Nilai Indeks Trombosit Dan Rasio Trombosit Limfosit Sebagai Penanda Inflamasi Glomerulus Pada Penderita Hipertensi Berbagai Derajat. Medica Arteriana (Med-Art), 1(2), 59-65. https://doi.org/10.26714/medart.1.2.2019.7-14
Tsokos, G. C. (2020). Autoimmunity and organ damage in systemic lupus erythematosus. Nature immunology, 21(6), 605-614. https://doi.org/10.1038/s41590-020-0677-6
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Hilya Saputri, Syalwa Arsa, Firdus Firdus, Rosnizar Rosnizar (Author)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.



